NfκBin: a machine learning based method for screening TNF-α induced NF-κB inhibitors

NfκBin: a machine learning based method for screening TNF-α induced NF-κB inhibitors

IntroductionNuclear Factor kappa B (NF-κB) is a transcription factor whose upregulation is associated in chronic inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. In order to develop therapeutic strategies targeting NF-κB-related diseases, we developed a...

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Bibliographic Details
Main Authors: Shipra Jain, Ritu Tomer, Sumeet Patiyal, Gajendra P. S. Raghava
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioinformatics
Subjects:
NF-κB
nuclear factor kappa B
machine learning
chemical descriptors
high-throughput screening
inhibitor prediction tool
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1573744/full
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https://www.frontiersin.org/articles/10.3389/fbinf.2025.1573744/full

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