Sulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner

Sulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner

<i>Desulfovibrio</i>, resident gut sulfate-reducing bacteria (SRB), are found to overgrow in diseases such as inflammatory bowel disease and Parkinson’s disease. They activate a pro-inflammatory response, suggesting that <i>Desulfovibrio</i> may play a causal role in inflamma...

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Bibliographic Details
Main Authors: Sudha B. Singh, Cody A. Braun, Amanda Carroll-Portillo, Cristina N. Coffman, Henry C. Lin
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Microorganisms
Subjects:
<i>Desulfovibrio vulgaris</i> (DSV)
inducible nitric oxide synthase (iNOS)
phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) (PI3K/AKT)
toll-like receptor 2 (TLR 2)
tumor necrosis factor-α (TNF-α)
Online Access:https://www.mdpi.com/2076-2607/12/9/1833
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