The Relation between Endothelial Monocyte-activating Polypeptide II and Polymorphism of Endothelin-1 Gene (G8002A) and Their Effect on Renal Function in Adolescent Patients with Beta-thalassemia Major

BACKGROUND: Iron overload, chronic anemia in addition to particular chelators of iron are considered the key factors in kidney impairment pathogenesis in beta-thalassemia major (β-TM). “Endothelin-1 (ET-1) is a very potent endogenous vasoconstrictor” that plays as a stimulator for reactive oxygen sp...

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Bibliographic Details
Main Authors: Dahlia N. Al-Saidi, Sumaya Saady, Zainab Walid Abdul Ameer
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Journal of Applied Hematology
Subjects:
Online Access:https://journals.lww.com/10.4103/joah.joah_121_24
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