MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

Abstract Mutations in MECP2 cause several neurological disorders of which Rett syndrome (RTT) represents the best‐defined condition. Although mainly working as a transcriptional repressor, MeCP2 is a multifunctional protein revealing several activities, the involvement of which in RTT remains obscur...

Full description

Saved in:
Bibliographic Details
Main Authors: Angelisa Frasca, Eleonora Spiombi, Michela Palmieri, Elena Albizzati, Maria Maddalena Valente, Anna Bergo, Barbara Leva, Charlotte Kilstrup‐Nielsen, Federico Bianchi, Valerio Di Carlo, Ferdinando Di Cunto, Nicoletta Landsberger
Format: Article
Language:English
Published: Springer Nature 2020-05-01
Series:EMBO Molecular Medicine
Subjects:
MeCP2
primary cilium
Rett syndrome
sonic hedgehog
tubacin treatment
Online Access:https://doi.org/10.15252/emmm.201910270
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.201910270

Similar Items