Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance

Abstract SSNA1 is a fibrillar protein involved in dynamic microtubule remodeling, including nucleation, co-polymerization, and microtubule branching. The underlying molecular mechanism has remained unclear due to a lack of structural information. Here, we determine the cryo-EM structure of C.elegans...

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Bibliographic Details
Main Authors: Lorenzo Agostini, Jason A. Pfister, Nirakar Basnet, Jienyu Ding, Rui Zhang, Christian Biertümpfel, Kevin F. O’Connell, Naoko Mizuno
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62696-9
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