CD4+T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions

CD4+T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions

Abstract Mechanical forces acting on ligand-engaged T-cell receptors (TCR) have previously been implicated in T-cell antigen recognition and ligand discrimination, yet their magnitude, frequency, and impact remain unclear. Here, we quantitatively assess forces across various TCR:pMHC pairs with diff...

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Main Authors: Lukas Schrangl, Florian Kellner, René Platzer, Vanessa Mühlgrabner, Paul Hubinger, Josephine Wieland, Reinhard Obst, José L. Toca-Herrera, Johannes B. Huppa, Gerhard J. Schütz, Janett Göhring
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62104-2
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https://doi.org/10.1038/s41467-025-62104-2

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