Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness

Type 2 (T2) inflammation underlies a substantial subset of moderate-to-severe asthma, contributing to persistent symptoms and frequent exacerbations. Dupilumab, a fully human immunoglobulin G subclass 4 (IgG4) monoclonal antibody, targets the interleukin-4 receptor alpha (IL-4Rα), thereby inhibiting...

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Bibliographic Details
Main Authors: Omar Z. Ameer, Ghaith K. Mansour, Raghad S. Al-Amoudi, Fahmi M. Abu‐Owaimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1631321/full
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