N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

Abstract N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expres...

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Main Authors: Kao-Jung Chang, Li-Yang Shiau, Shiuan-Chen Lin, Han-Ping Cheong, Ching-Yun Wang, Chun Ma, Yan-Wen Liang, Yi-Ping Yang, Po-Shen Ko, Chih-Hung Hsu, Shih-Hwa Chiou
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
m6A
HSCs
Lymphocytes
Leukemia
Lymphoma
Online Access:https://doi.org/10.1186/s10020-024-00965-x
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https://doi.org/10.1186/s10020-024-00965-x

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