Nrf2 negatively regulates melanogenesis by modulating PI3K/Akt signaling.

Nrf2 negatively regulates melanogenesis by modulating PI3K/Akt signaling.

Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect of Nrf2 on melanogenesis in normal human melanocytes (NHMCs). When NHMCs were transduced with a recombinant adenovirus expressing Nrf2...

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Main Authors: Jung-Min Shin, Mi Yoon Kim, Kyung-Cheol Sohn, So-Young Jung, Hae-Eul Lee, Jae Woo Lim, Sooil Kim, Young-Ho Lee, Myung Im, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee, Young Lee, Tae-Jin Yoon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096035&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096035&type=printable

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