Role of circulating tumor DNA in early-stage triple-negative breast cancer: a systematic review and meta-analysis

Role of circulating tumor DNA in early-stage triple-negative breast cancer: a systematic review and meta-analysis

Abstract Background Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and carries a worse prognosis relative to other breast cancer subtypes. This systematic review and meta-analysis evaluated the prognostic value of circulating tumor DNA (ctDNA) in early-stage TNBC. Method...

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Main Authors: Diana Zhang, Shayesteh Jahanfar, Judy B. Rabinowitz, Joshua Dower, Fei Song, Cherng-Horng Wu, Xiao Hu, Phillip Tracy, Mark Basik, Arielle Medford, Po-Han Lin, Chiun-Sheng Huang, Francois-Clement Bidard, Shufang Renault, Lori Pai, Mary Buss, Heather A. Parsons, Ilana Schlam
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Breast Cancer Research
Subjects:
Circulating tumor DNA
Triple-negative breast cancer
Prognosis
Recurrence-free survival
Disease free survival
Overall survival
Online Access:https://doi.org/10.1186/s13058-025-01986-y
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https://doi.org/10.1186/s13058-025-01986-y

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