Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity

Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity

Abstract The intratumoral immune milieu is crucial for the success of anti-cancer immunotherapy. We show here that stromal modulation by the tubulin-binding anti-cancer drugs combretastatin A4 (CA-4) and eribulin improved tumor perfusion and anti-tumor immunity. This was achieved by reverting highly...

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Main Authors: Bo He, Kira H Wood, Zhi-jie Li, Judith A Ermer, Ji Li, Edward R Bastow, Suraj Sakaram, Phillip K Darcy, Lisa J Spalding, Cameron T Redfern, Jordi Canes, Mafalda Oliveira, Aleix Prat, Javier Cortes, Erik W Thompson, Bruce A Littlefield, Andrew Redfern, Ruth Ganss
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Angiogenesis
Pericytes
Microtubule-binding Drugs
Tumor Immunity
Rho Kinase
Online Access:https://doi.org/10.1038/s44321-025-00222-6
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https://doi.org/10.1038/s44321-025-00222-6

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