Cell based high-throughput screening for small molecule inhibitors of ATE1

Cell based high-throughput screening for small molecule inhibitors of ATE1

Arginyltransferase 1 (ATE1) catalyzes post-translational arginylation, a process implicated in protein stability, cellular function, and disease pathology. Dysregulated arginylation is associated with neurodegenerative disorders, cancer, and inflammation. Particularly, the increase of ATE1 activity...

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Bibliographic Details
Main Authors: Claudia McCown, Evan A. Ambrose, Devang M. Patel, Hassan Al-Ali, Louis Scampavia, Fangliang Zhang, Timothy P. Spicer
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:SLAS Discovery
Subjects:
Arginyltransferase 1
Cell-based
ATE1
uHTS
Multiplex readout
UF Scripps
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000565
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