Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses.

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses.

The pandemic spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of Coronavirus Disease 2019 (COVID-19), represents an ongoing international health crisis. A key symptom of SARS-CoV-2 infection is the onset of fever, with a hyperthermic temperature range of...

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Main Authors: Vanessa Herder, Kieran Dee, Joanna K Wojtus, Ilaria Epifano, Daniel Goldfarb, Christoforos Rozario, Quan Gu, Ana Da Silva Filipe, Kyriaki Nomikou, Jenna Nichols, Ruth F Jarrett, Andrew Stevenson, Steven McFarlane, Meredith E Stewart, Agnieszka M Szemiel, Rute M Pinto, Andreu Masdefiol Garriga, Chris Davis, Jay Allan, Sheila V Graham, Pablo R Murcia, Chris Boutell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001065&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001065&type=printable

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