Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch

Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch

Abstract Background Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges. To address the safety concern, this study aims to establish a proof-o...

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Main Authors: Mohammad Izadifar, Mohammad Massumi, Kacey J. Prentice, Tatiana Oussenko, Biao Li, Judith Elbaz, Mira Puri, Michael B. Wheeler, Andras Nagy
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Stem cells
Beta cells
Type 1 diabetes
Cell therapy
Cell reprogramming
Organ on chip
Online Access:https://doi.org/10.1186/s13287-024-04059-7
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https://doi.org/10.1186/s13287-024-04059-7

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