Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

<h4>Background</h4>Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed wh...

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Main Authors: Sandra Soeria-Atmadja, Emma Österberg, Lars L Gustafsson, Marja-Liisa Dahl, Jaran Eriksen, Johanna Rubin, Lars Navér
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181316&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181316&type=printable

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