The Gut Microbiota Affects Anti‐TNF Responsiveness by Activating the NAD+ Salvage Pathway in Ulcerative Colitis

The Gut Microbiota Affects Anti‐TNF Responsiveness by Activating the NAD+ Salvage Pathway in Ulcerative Colitis

Abstract Approximately 50% of the patients with ulcerative colitis (UC) are primarily nonresponsive to anti‐tumor necrosis factor (TNF) therapy or lose their responsiveness over time. The gut microbiota plays an important role in the resistance of UC to anti‐TNF therapy; however, the underlying mech...

Full description

Saved in:
Bibliographic Details
Main Authors: Jing Lei, Lin Lv, Li Zhong, Feng Xu, Wenhao Su, Yan Chen, Zhixuan Wu, Song He, Yongyu Chen
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
anti‐tumor necrosis factor therapy
fusobacterium nucleatum
microbiota
NAD+ salvage pathway
ulcerative colitis
Online Access:https://doi.org/10.1002/advs.202413128
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202413128

Similar Items