FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway

FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway

ObjectiveThe Fibroblast growth factor receptors 3-transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3, F3-T3) oncogenic fusion gene, identified in malignant tumors such as gliomas and bladder cancer, has been particularly noted in recurrent gliomas where it is considered to drive malig...

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Bibliographic Details
Main Authors: Yiming Li, Jianshen Liang, Xiude Ren, Jiahe Guo, Xisen Wang, Xuya Wang, Shengping Yu, Tao Li, Xuejun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
FGFR3-TACC3 fusion gene
glioma
malignant progression
invasion
migration
STAT3 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1560008/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1560008/full

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