Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway

Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly population. It is characterized by cognitive deficits associated with the accumulation of amyloid-beta plaques and neurofibrillary tangles. Huang-Lian-Jie-Du (HLJD) decoction,...

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Bibliographic Details
Main Authors: Rui-Kang Pang, Jia Shi, Xiang-Yu Peng, Shan Su, Jia-Yi Zheng, Kai Le, Vincent W. Keng, Shi-Jie Zhang, Xiao-Xiao Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Chinese Medicine
Subjects:
Alzheimer’s disease
Huang-Lian-Jie-Du decoction
Microglia
Neuroinflammation
Trem2
Dap12
Online Access:https://doi.org/10.1186/s13020-025-01098-x
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https://doi.org/10.1186/s13020-025-01098-x

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