Overcoming Antigen Escape and T-Cell Exhaustion in CAR-T Therapy for Leukemia

Overcoming Antigen Escape and T-Cell Exhaustion in CAR-T Therapy for Leukemia

Leukemia is a prevalent pediatric cancer with significant challenges, particularly in relapsed or refractory cases. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a personalized cancer treatment, modifying patients’ T cells to target and destroy resistant cancer cells. This study re...

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Bibliographic Details
Main Authors: Elżbieta Bartoszewska, Maciej Tota, Monika Kisielewska, Izabela Skowron, Kamil Sebastianka, Oliwia Stefaniak, Klaudia Molik, Jakub Rubin, Karolina Kraska, Anna Choromańska
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Cells
Subjects:
leukemia
pediatric oncology
CAR-T therapy
acute lymphoblastic leukemia
acute myeloid leukemia
antigen escape
Online Access:https://www.mdpi.com/2073-4409/13/18/1596
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