Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy

Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy

BackgroundPrimary Membranous Nephropathy (PMN) is characterized by dysregulated immune responses, with B cells playing critical roles in disease pathogenesis. However, the immunopathogenic mechanisms underlying B cell involvement in PMN remain elusive.MethodsWe employed single-cell RNA sequencing on...

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Bibliographic Details
Main Authors: Fang Lu, Si Chen, Honglei Guo, Qing Li, Lin Wu, Ying Pan, Yangfan Wu, Hua Shu, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Hongwei Liang, Suyan Duan, Yanggang Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
ScRNA-seq
PBMC
PMN
galectin-9
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622395/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622395/full

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