Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology

Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology

IntroductionApolipoprotein E (ApoE) plays a crucial role in lipid homeostasis, predominantly expressed in astrocytes and to a lesser extent in microglia within the central nervous system (CNS). While the APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), its p...

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Bibliographic Details
Main Authors: Printha Wijesinghe, Hao Ran Li, Zhengyuan Ai, Matthew Campbell, Si Xuan Chen, Jeanne Xi, Wellington Pham, Joanne A. Matsubara
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
apolipoprotein E
Alzheimer’s disease
microRNAs
amyloid peptide
astroglia
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1495615/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1495615/full

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