Missense variants in FRS3 affect body mass index in populations of diverse ancestries

Missense variants in FRS3 affect body mass index in populations of diverse ancestries

Abstract Obesity is associated with adverse effects on health and quality of life. Improved understanding of its underlying pathophysiology is essential for developing counteractive measures. To search for sequence variants with large effects on BMI, we perform a multi-ancestry meta-analysis of 13 g...

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Main Authors: Andrea B. Jonsdottir, Gardar Sveinbjornsson, Rosa B. Thorolfsdottir, Max Tamlander, Vinicius Tragante, Thorhildur Olafsdottir, Solvi Rognvaldsson, Asgeir Sigurdsson, Hannes P. Eggertsson, Hildur M. Aegisdottir, David O. Arnar, Karina Banasik, Doruk Beyter, Ragnar G. Bjarnason, Gyda Bjornsdottir, Søren Brunak, Mie Topholm Bruun, Joseph Dowsett, Eythor Einarsson, Gudmundur Einarsson, Christian Erikstrup, Run Fridriksdottir, Jonas Ghouse, Solveig Gretarsdottir, Gisli H. Halldorsson, Torben Hansen, Anna Helgadottir, Peter C. Holm, Erna V. Ivarsdottir, Kasper Karmark Iversen, Bitten Aagaard Jensen, Ingileif Jonsdottir, Stacey Knight, Kirk U. Knowlton, Snaedis Kristmundsdottir, Adalheidur E. Larusdottir, Olafur Th. Magnusson, Gisli Masson, Pall Melsted, Christina Mikkelsen, Kristjan H. S. Moore, Asmundur Oddsson, Pall I. Olason, Frosti Palsson, Ole Birger Pedersen, Michael Schwinn, Emil L. Sigurdsson, Aron Skaftason, Lilja Stefansdottir, Hreinn Stefansson, Thora Steingrimsdottir, Arni Sturluson, Unnur Styrkarsdottir, Erik Sørensen, Unnur D. Teitsdottir, Thorgeir E. Thorgeirsson, Gudmundur A. Thorisson, Unnur Thorsteinsdottir, Magnus O. Ulfarsson, Henrik Ullum, Arnor Vikingsson, G. Bragi Walters, DBDS Genomic Consortium, Lincoln D. Nadauld, Henning Bundgaard, Sisse Rye Ostrowski, Agnar Helgason, Bjarni V. Halldorsson, Gudmundur L. Norddahl, Samuli Ripatti, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Hilma Holm, Patrick Sulem, Kari Stefansson
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57753-2
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https://doi.org/10.1038/s41467-025-57753-2

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