Granzyme B and melittin in cancer immunotherapy: molecular mechanisms and therapeutic perspectives in head and neck cancers

Granzyme B and melittin in cancer immunotherapy: molecular mechanisms and therapeutic perspectives in head and neck cancers

Granzyme B (GZMB) and melittin are potent cytotoxic agents with promising applications in cancer immunotherapy, particularly in head and neck squamous cell carcinoma (HNSC). GZMB, secreted by cytotoxic T lymphocytes and natural killer (NK) cells, induces apoptosis through caspase activation and mito...

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Bibliographic Details
Main Authors: Adam Majchrzak, Filip Lewandowski, Rafał Hrynkiewicz, Agata Poniewierska-Baran, Dominika Bębnowska, Paulina Niedźwiedzka-Rystwej
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
granzyme B
melittin
hNSC
cytotoxicity
NK cells
CTL
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1628014/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1628014/full

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