Stress exposure affects amyotrophic lateral sclerosis pathogenesis via PI3K/Akt and focal adhesion pathways: evidence from three experimental models

Stress exposure affects amyotrophic lateral sclerosis pathogenesis via PI3K/Akt and focal adhesion pathways: evidence from three experimental models

Abstract Amyotrophic lateral sclerosis (ALS) is a multifactorial motor neuron (MN) disease, characterized by several cellular dysfunctions, many of which are shared by different neurodegenerative diseases. Here, we investigated whether a stressful lifestyle might exacerbate the altered mechanisms an...

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Bibliographic Details
Main Authors: Daniela Maria Rasà, Ilaria Stoppa, Noémie Bérenger-Currias, Elena Pasho, Sorana Ciura, Edor Kabashi, Cécile Martinat, Marina Boido
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Bioinformatic analysis
Exposome
Molecular mechanisms
Neuromuscular disease
Stressor
Online Access:https://doi.org/10.1038/s41598-025-02167-9
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https://doi.org/10.1038/s41598-025-02167-9

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