Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3

Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3

Abstract Background Hemorrhagic cystitis (HC), a frequent complication of hematopoietic stem cell transplantation (HSCT), significantly affects quality of life and may worsen prognosis. Mesenchymal stem cells (MSCs) are known for their anti-inflammatory and tissue-regenerative properties. IL-1 recep...

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Bibliographic Details
Main Authors: Jialin Song, Yanxiao Han, Yuyan Chen, Lin Cheng, Juan Xiao, Ai Li, Dexiao Kong, Yang Jiang, Chengyun Zheng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Hemorrhagic cystitis
Mesenchymal stem cell
Migration
HtrA serine peptidase 3
Interleukin-1 receptor antagonist
Online Access:https://doi.org/10.1186/s13287-025-04443-x
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https://doi.org/10.1186/s13287-025-04443-x

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