CHEK1 is a synthetic lethal interactor of FBXO7 in colonic epithelial cells
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, with chromosome instability (CIN) present in approximately 85% of cases and associated with poor prognosis. Reduced expression of FBXO7, a component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex, occurs in abou...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Molecular Therapy: Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329925000979 |
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