GSD-SSR: an integrated framework for power analysis in IRB proposals using group sequential design and sample size re-estimation

Accurate sample size estimation is a cornerstone of successful Institutional Review Board (IRB) proposals, as it establishes the feasibility of clinical studies and ensures they are sufficiently powered to detect meaningful effects. Underestimating sample size poses the risk of insufficient statisti...

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Bibliographic Details
Main Authors: Yuxi Zhu, Shi Du, Peihe Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Applied Mathematics and Statistics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fams.2025.1611205/full
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