Application of a new green protocol in solid-phase peptide synthesis: identification of a new green solvent mixture compatible with TBEC/ETT

Application of a new green protocol in solid-phase peptide synthesis: identification of a new green solvent mixture compatible with TBEC/ETT

Solid Phase Peptide Synthesis (SPPS) is the preferred technique for synthesizing bioactive peptides. However, traditional SPPS generates significant waste and employs hazardous solvents like DMF and DCM. The aim of this research is to investigate solvents and agents of coupling that align with the g...

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Bibliographic Details
Main Authors: Giovanni Vivenzio, Maria Carmina Scala, Giulia Auriemma, Carla Sardo, Pietro Campiglia, Marina Sala
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Green Chemistry Letters and Reviews
Subjects:
Solid-phase peptide synthesis
Fluorenylmethoxycarbonyl (Fmoc)
green solvents
mixtures
coupling reagents
Online Access:https://www.tandfonline.com/doi/10.1080/17518253.2024.2404234
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https://www.tandfonline.com/doi/10.1080/17518253.2024.2404234

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