The Parkinson’s drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis

The Parkinson’s drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis

Abstract Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) evade host defence mechanisms to infect and survive within host cells. Host-directed therapy (HDT) offers a promising alternative to antibiotics and may overcome antimicrobial resistance. Using high-content screening, we ident...

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Main Authors: Henok A. Sahile, Matthew Christofferson, Morgan A. Alford, Celine Rens, Hasti Haghdadi, Joseph D. Chao, Georgia Langdon, Robert E. W. Hancock, Jeffrey Chen, Yossef Av-Gay
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-025-00143-x
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https://doi.org/10.1038/s44259-025-00143-x

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