Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence
The human endogenous retroviruses (HERVs) are ancient exogenous retroviruses that were embedded in the germline over 30 million years ago and underwent an endogenization process. They make up roughly 8% of the human genome. HERVs exhibit many physiological and non-physiological functions; for exampl...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/1/59 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589001562783744 |
|---|---|
| author | Patrycja Kozubek Julia Kuźniar Magdalena Czaja Hanna Sitka Urszula Kochman Jerzy Leszek |
| author_facet | Patrycja Kozubek Julia Kuźniar Magdalena Czaja Hanna Sitka Urszula Kochman Jerzy Leszek |
| author_sort | Patrycja Kozubek |
| collection | DOAJ |
| description | The human endogenous retroviruses (HERVs) are ancient exogenous retroviruses that were embedded in the germline over 30 million years ago and underwent an endogenization process. They make up roughly 8% of the human genome. HERVs exhibit many physiological and non-physiological functions; for example, they play a role in the development of many diseases. They have been shown to affect carcinogenesis by modifying the expression of host genes through their functions as enhancers and promoters. Additionally, some molecules derived from HERVs may stimulate the immune system. Recently research has been focused on the effect of human endogenous retroviruses on the development of neurodegenerative diseases, including Alzheimer’s disease (AD), which is the most common cause of dementia. AD is also linked to a significant deterioration in quality of life. The article aims to highlight the potential role of HERVs in neurodegenerative diseases such as Alzheimer’s disease and senescence. Moreover, it is estimated that HERVs may be potential targets for diagnosis and therapy of AD. |
| format | Article |
| id | doaj-art-b2044d16e2cd44b1a69732cd66c851c4 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-b2044d16e2cd44b1a69732cd66c851c42025-01-24T13:23:52ZengMDPI AGBiomedicines2227-90592024-12-011315910.3390/biomedicines13010059Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and SenescencePatrycja Kozubek0Julia Kuźniar1Magdalena Czaja2Hanna Sitka3Urszula Kochman4Jerzy Leszek5Student Scientific Group of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandDepartment of Psychiatry, Faculty of Medicine, Wroclaw Medical University, 50-369 Wroclaw, PolandThe human endogenous retroviruses (HERVs) are ancient exogenous retroviruses that were embedded in the germline over 30 million years ago and underwent an endogenization process. They make up roughly 8% of the human genome. HERVs exhibit many physiological and non-physiological functions; for example, they play a role in the development of many diseases. They have been shown to affect carcinogenesis by modifying the expression of host genes through their functions as enhancers and promoters. Additionally, some molecules derived from HERVs may stimulate the immune system. Recently research has been focused on the effect of human endogenous retroviruses on the development of neurodegenerative diseases, including Alzheimer’s disease (AD), which is the most common cause of dementia. AD is also linked to a significant deterioration in quality of life. The article aims to highlight the potential role of HERVs in neurodegenerative diseases such as Alzheimer’s disease and senescence. Moreover, it is estimated that HERVs may be potential targets for diagnosis and therapy of AD.https://www.mdpi.com/2227-9059/13/1/59human endogenous retrovirusesAlzheimer’s diseasesenescenceneurodegeneration |
| spellingShingle | Patrycja Kozubek Julia Kuźniar Magdalena Czaja Hanna Sitka Urszula Kochman Jerzy Leszek Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence Biomedicines human endogenous retroviruses Alzheimer’s disease senescence neurodegeneration |
| title | Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence |
| title_full | Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence |
| title_fullStr | Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence |
| title_full_unstemmed | Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence |
| title_short | Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence |
| title_sort | human endogenous retroviruses and their putative role in pathogenesis of alzheimer s disease inflammation and senescence |
| topic | human endogenous retroviruses Alzheimer’s disease senescence neurodegeneration |
| url | https://www.mdpi.com/2227-9059/13/1/59 |
| work_keys_str_mv | AT patrycjakozubek humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence AT juliakuzniar humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence AT magdalenaczaja humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence AT hannasitka humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence AT urszulakochman humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence AT jerzyleszek humanendogenousretrovirusesandtheirputativeroleinpathogenesisofalzheimersdiseaseinflammationandsenescence |