Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury

Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury

IntroductionAnemoside B4 (AB4), a major bioactive saponin isolated from the roots of Pulsatilla chinensis, exhibits anti-inflammatory and antioxidant properties. While recent study has demonstrated its ability to inhibit ferroptosis in arthritis, its role in sepsis-induced acute lung injury (SALI) r...

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Bibliographic Details
Main Authors: Yue Bu, Zhixi Li, Cheng Wang, Yongjing Yu, Chang Liu, Yue Sun, Zhenyu Sun, Weidong Gong, Juan Luo, Ziyong Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
anemoside B4
sepsis
acute lung injury
ferroptosis
network pharmacology
AGE/RAGE pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590797/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1590797/full

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