The KLF16/MYC feedback loop is a therapeutic target in bladder cancer

The KLF16/MYC feedback loop is a therapeutic target in bladder cancer

Abstract Background Bladder cancer (BLCA) is a common malignancy characterized by dysregulated transcription and a lack of effective therapeutic targets. In this study, we aimed to identify and evaluate novel targets with clinical potential essential for tumor growth in BLCA. Methods CRISPR-Cas9 scr...

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Main Authors: Lisi Zheng, Jingxuan Wang, Shan Han, Li Zhong, Zefu Liu, Bin Li, Ruhua Zhang, Liwen Zhou, Xianchong Zheng, Zhenhua Liu, Cuiling Zeng, Ruonan Li, Yezi Zou, Liqin Wang, Yuanzhong Wu, Tiebang Kang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KLF16
MYC
Bladder cancer
BET inhibitors
Chemotherapy sensitivity
Online Access:https://doi.org/10.1186/s13046-024-03224-3
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https://doi.org/10.1186/s13046-024-03224-3

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