Differential patterns of cross-protection against antigenically distinct variants in small animal models of SARS-CoV-2 infection

Abstract Continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will likely necessitate periodic updates of vaccine composition. Based on a series of studies carried out in human ACE2 transgenic mice (K18-hACE2) and Syrian hamsters, we show that immunity at the respirat...

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Bibliographic Details
Main Authors: Prabhuanand Selvaraj, Charles B. Stauft, Shufeng Liu, Kotou Sangare, Tony T. Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00125-w
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