Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids

Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids

Abstract Background Neuronal spheroids represent an easy and versatile solution to model neuronal tissue in vitro. Conventional approaches to generate spheroids lack accurate size control, scalability, and customizability. This is even more exacerbated in case of pluripotent stem cell (PSC) derived...

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Main Authors: Eleonora Mello, Stefano Sorrentino, Alessio Bucciarelli, Ermanno Cordelli, Elisa De Luca, Haakon Nygaard, Stefan Wendt, Alberto Rainer, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Pamela Mozetic
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Neuronal spheroids
Motor neurons
Microwell
HiPSCs
MNX1
ISL1
Online Access:https://doi.org/10.1186/s13287-025-04547-4
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https://doi.org/10.1186/s13287-025-04547-4

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