First preclinical SPECT/CT imaging and biodistribution of [165Er]ErCl3 and [165Er]Er-PSMA-617

First preclinical SPECT/CT imaging and biodistribution of [165Er]ErCl3 and [165Er]Er-PSMA-617

Abstract Background 165Er (t1/2 = 10.4 h, Ex-ray = 47.1 keV (59.4%) and 54.3 keV (14.3%)) is a promising radionuclide suitable for targeted Auger electron therapy of cancer. 165Er can be produced at a relatively low cost, high yield, and high purity using small medical cyclotrons. As a late lanthani...

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Bibliographic Details
Main Authors: Behrad Saeedi Saghez, Cristina Rodríguez-Rodríguez, Pedro Luis Esquinas, Helen Merkens, François Bénard, Valery Radchenko, Hua Yang
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
165Er
Erbium-165
Auger electron emitter
Phantom imaging
SPECT imaging
Preclinical study
Online Access:https://doi.org/10.1186/s41181-024-00312-9
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https://doi.org/10.1186/s41181-024-00312-9

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