Anti-Inflammatory Potential of Umckalin Through the Inhibition of iNOS, COX-2, Pro-Inflammatory Cytokines, and MAPK Signaling in LPS-Stimulated RAW 264.7 Cells

Anti-Inflammatory Potential of Umckalin Through the Inhibition of iNOS, COX-2, Pro-Inflammatory Cytokines, and MAPK Signaling in LPS-Stimulated RAW 264.7 Cells

<b>Background/Objectives</b>: Umckalin, a coumarin derivative abundantly present in the root extract of Pelargonium sidoides, is a key bioactive compound known for its antimicrobial, antiviral, antitubercular, and immunomodulatory properties. Its therapeutic potential has been extensivel...

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Bibliographic Details
Main Authors: So-Yeon Oh, Chang-Gu Hyun
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Future Pharmacology
Subjects:
anti-inflammation
coumarin
RAW 264.7 macrophages
<i>Pelargonium sidoides</i>
signaling pathway
umckalin
Online Access:https://www.mdpi.com/2673-9879/5/1/6
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