mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs

mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs

Abstract This study evaluated the effectiveness of N1-methylpseudouridine-modified mRNA encoding bone morphogenetic protein-2 (BMP-2 mRNA-LNP) in promoting bone growth and improving titanium implant integration in rat femur bone defects. Sixteen Sprague-Dawley rats (32 femurs) were used, with titani...

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Main Authors: Kanoksiri Jriyasetapong, Nopparada Lawtrakulngam, Philaiporn Vivatbutsiri, Sunporn Namano, Kamolporn Wattanasirmkit, Somphote Angkhanawiriyarak, Jaijam Suwanwela
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Bone morphogenetic Protein-2 (BMP-2)
Dental implant
Bone regeneration
Peri-implant bone formation
mRNA
Preclinical studies
Online Access:https://doi.org/10.1038/s41598-025-02931-x
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https://doi.org/10.1038/s41598-025-02931-x

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