Males and females respond differently to treatment during isolated kidney perfusion: combined effects of glucocorticoid and estradiol

Males and females respond differently to treatment during isolated kidney perfusion: combined effects of glucocorticoid and estradiol

BackgroundKidney perfusion is a tool that allows organs to be assessed before transplantation. After brain death (BD), hormonal dysfunction can compromise graft quality. Hormonal treatment of donors has shown positive outcomes, and treatment during ex vivo perfusion may be advantageous. The combinat...

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Main Authors: Marina Vidal-dos-Santos, Roberto Armstrong-Jr, Mayara Munhoz de Assis Ramos, Lucas Ferreira da Anunciação, Fernanda Yamamoto Ricardo-da-Silva, Cristiano de Jesus Correia, Petra J. Ottens, Luiz Felipe Pinho Moreira, Henri G. D. Leuvenink, Ana Cristina Breithaupt-Faloppa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Transplantation
Subjects:
brain death
sex differences
machine perfusion
kidney
rat
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2025.1595766/full
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https://www.frontiersin.org/articles/10.3389/frtra.2025.1595766/full

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