Validation of high-throughput sequencing-based test system for detection of microsatellite instability in colorectal cancer samples

Validation of high-throughput sequencing-based test system for detection of microsatellite instability in colorectal cancer samples

Introduction. Currently in routine clinical practice, standard methods based on polymerase chain reaction (PCR) and immunohistochemical examination are used to determine microsatellite instability (MSI) and deficient mismatch repair system (dMMR). MSI identification using high-throughput sequencing...

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Main Authors: A. A. Lebedeva, A. N. Taraskina, A. I. Kavun, E. V. Belova, T. V. Grigor'eva, O. A. Kuznetsova, D. A. Kravchuk, L. D. Belyaeva, V. E. Nikulin, E. D. Khomenko, V. A. Mileyko, A. A. Tryakin, M. Yu. Fedyanin, M. V. Ivanov
Format: Article
Language:Russian
Published: ABV-press 2025-04-01
Series:Успехи молекулярной онкологии
Subjects:
high-throughput sequencing
next generation sequencing
microsatellite
Online Access:https://umo.abvpress.ru/jour/article/view/756
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