Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma

Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma

Background Desmoplastic melanoma (DM) is a rare melanoma subtype characterized by dense fibrous stroma, a propensity for local recurrence, and a high response rate to programmed cell death protein 1 (PD-1) blockade. Occult sentinel lymph node positivity is significantly lower in both pure and mixed...

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Main Authors: Ruth Halaban, Kelly Olino, James Clune, David L Rimm, Harriet M Kluger, Dijana Djureinovic, Wael Ibrahim, Raymond Baumann, Anjela Galan, David G Su, David A. Schoenfeld, Raysa Cabrejo, Sajid A Khan
Format: Article
Language:English
Published: BMJ Publishing Group 2024-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/3/e008646.full
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https://jitc.bmj.com/content/12/3/e008646.full

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