Glioma-neuronal circuit remodeling induces regional immunosuppression

Glioma-neuronal circuit remodeling induces regional immunosuppression

Abstract Neuronal activity-driven mechanisms influence glioblastoma cell proliferation and invasion, while glioblastoma remodels neuronal circuits. Although a subpopulation of malignant cells enhances neuronal connectivity, their impact on the immune system remains unclear. Here, we show that gliobl...

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Main Authors: Takahide Nejo, Saritha Krishna, Akane Yamamichi, Senthilnath Lakshmanachetty, Christian Jimenez, Kevin Y. Lee, Donovan L. Baker, Jacob S. Young, Tiffany Chen, Su Su Sabai Phyu, Lan Phung, Marco Gallus, Gabriella C. Maldonado, Kaori Okada, Hirokazu Ogino, Payal B. Watchmaker, David Diebold, Abrar Choudhury, Andy G. S. Daniel, Cathryn R. Cadwell, David R. Raleigh, Shawn L. Hervey-Jumper, Hideho Okada
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60074-z
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https://doi.org/10.1038/s41467-025-60074-z

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