Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses in Pseudomonas aeruginosa infections

Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses in Pseudomonas aeruginosa infections

Pseudomonas aeruginosa is a major opportunistic pathogen that causes chronic infections, particularly in patients with cystic fibrosis and chronic obstructive pulmonary disease (COPD). The type VI secretion system (T6SS) is a primary virulence factor of P. aeruginosa in chronic infections. The objec...

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Bibliographic Details
Main Authors: Yinglin Wu, Shan Huang, Kai Zhang, Yangcheng Shen, Shebin Zhang, Haining Xia, Jieying Pu, Cong Shen, Cha Chen, Jianming Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Pseudomonas aeruginosa
virulence
type VI secretion system
chaperone-usher pathway
CupC fimbriae
A549 epithelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1582339/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1582339/full

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