FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force

FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force

von Willebrand factor (vWF) is a large glycoprotein in the circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets in assembling clots. How vWF mechanosenses shear flow for molecular unfolding is an important topic. Here, a Förster resonance energy transf...

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Bibliographic Details
Main Authors: Mingxing Ouyang, Yao Gao, Binqian Zhou, Jia Guo, Lei Lei, Yingxiao Wang, Linhong Deng
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biosensors
Subjects:
von Willebrand factor
fluid shear
Förster resonance energy transfer (FRET)
mechanosensation
molecular unfolding
hemophilia
Online Access:https://www.mdpi.com/2079-6374/15/4/248
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