Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis

Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis

Abstract Gasdermin C is one of the least studied members of the gasdermin family of proteins, known for their critical involvement in pyroptosis and host defense. Furthermore, evidence for the role of Gasdermin C in the intestine is scarce and partly controversial. Here, we tested the functional rol...

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Main Authors: Reyes Gámez-Belmonte, Yara Wagner, Mousumi Mahapatro, Ru Wang, Lena Erkert, Miguel González-Acera, Roodline Cineus, Saskia Hainbuch, Jay V. Patankar, David Voehringer, Ahmed N. Hegazy, Markus F. Neurath, Stefan Wirtz, Christoph Becker
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Intestinal homeostasis
Gut pathology
Gasdermin
Online Access:https://doi.org/10.1038/s41598-024-78336-z
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https://doi.org/10.1038/s41598-024-78336-z

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