Cardiac‐specific succinate dehydrogenase deficiency in Barth syndrome

Cardiac‐specific succinate dehydrogenase deficiency in Barth syndrome

Abstract Barth syndrome (BTHS) is a cardiomyopathy caused by the loss of tafazzin, a mitochondrial acyltransferase involved in the maturation of the glycerophospholipid cardiolipin. It has remained enigmatic as to why a systemic loss of cardiolipin leads to cardiomyopathy. Using a genetic ablation o...

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Main Authors: Jan Dudek, I‐Fen Cheng, Arpita Chowdhury, Katharina Wozny, Martina Balleininger, Robert Reinhold, Silke Grunau, Sylvie Callegari, Karl Toischer, Ronald JA Wanders, Gerd Hasenfuß, Britta Brügger, Kaomei Guan, Peter Rehling
Format: Article
Language:English
Published: Springer Nature 2015-12-01
Series:EMBO Molecular Medicine
Subjects:
Barth syndrome
cardiolipin
mitochondria
respiratory chain
succinate dehydrogenase
Online Access:https://doi.org/10.15252/emmm.201505644
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https://doi.org/10.15252/emmm.201505644

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