T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.

<h4>Background</h4>Engagement of the β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), results in stabilization of T cell mRNA transcripts containing AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing protein, HuR. However, li...

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Bibliographic Details
Main Authors: Vinod S Ramgolam, Scott D DeGregorio, Gautham K Rao, Mark Collinge, Sharmila S Subaran, Silva Markovic-Plese, Ruggero Pardi, Jeffrey R Bender
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014450&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014450&type=printable

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