Scopoletin as a cardioprotective agent against cisplatin-induced oxidative stress and inflammation

Scopoletin as a cardioprotective agent against cisplatin-induced oxidative stress and inflammation

Background: Cisplatin (CP) is a chemotherapeutic agent notorious for its cardiotoxic effects. Scopoletin, a natural coumarin, has shown potential due to its antioxidant, anti-inflammatory, and anti-apoptotic properties, which may counteract CP-induced cardiotoxicity. Purpose: The study aimed to expl...

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Main Authors: Esam Qnais, Omar Gammoh, Yousra Bsieso, Mohammad Alqudah, Mohammad Wedyan, Sara Altaber, Alaa A.A. Aljabali, Abdelrahim Alqudah, Taher Hatahet
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Phytomedicine Plus
Subjects:
Scopoletin
Cisplatin
Cardiotoxicity
Nrf2
Oxidative stress
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031325000119
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