GDNF and cAMP significantly enhance in vitro blood-brain barrier integrity in a humanized tricellular transwell model

GDNF and cAMP significantly enhance in vitro blood-brain barrier integrity in a humanized tricellular transwell model

Blood-brain barrier (BBB) is a crucial membrane safeguarding neural tissue by controlling the molecular exchange between blood and the brain. However, assessing BBB permeability presents challenges for central nervous system (CNS) drug development. In vitro studies of BBB-permeable agents before ani...

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Bibliographic Details
Main Authors: Phongthon Kanjanasirirat, Witchuda Saengsawang, Pimonrat Ketsawatsomkron, Nithi Asavapanumas, Suparerk Borwornpinyo, Sunhapas Soodvilai, Suradej Hongeng, Sitthivut Charoensutthivarakul
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Blood-brain barrier permeability
Blood-brain barrier integrity
Neurovascular unit
Drug development
In vitro blood-brain barrier
Triculture model
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024153741
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