α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway

α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway

IntroductionDiabetic cardiomyopathy (DCM), a cardiac complication of diabetes, is the main cause of the high prevalence of heart failure and associated mortality in diabetic patients. Oxidative stress and lipid metabolism disorder-induced myocardial cell damage are part of the pathogenesis of DCM. I...

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Bibliographic Details
Main Authors: Xue Bai, Ziqian Zhang, Miao Zhang, Jiaojiao Xu, Keting Dong, Qian Du, Lei Chen, Ping Ma, Jianhong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
diabetic cardiomyopathy
alpha-mangostin
oxidative damage
lipotoxicity
forkhead box class O1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1566311/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1566311/full

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