Rational Design, Synthesis, and In Vitro Activity of Heterocyclic Gamma-Butyrobetaines as Potential Carnitine Acetyltransferase Inhibitors

Rational Design, Synthesis, and In Vitro Activity of Heterocyclic Gamma-Butyrobetaines as Potential Carnitine Acetyltransferase Inhibitors

This study investigates heterocyclic gamma-butyrobetaine (GBB) analogs as metabolic modulators through an integrated approach involving rational design, molecular docking, synthesis, and in vitro evaluation. The compounds synthesized demonstrated promising inhibitory potential toward carnitine acety...

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Bibliographic Details
Main Authors: Savina Stoyanova, Milen G. Bogdanov
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
carnitine acyltransferase
L-carnitine
fatty acid oxidation
enzyme inhibition
Online Access:https://www.mdpi.com/1420-3049/30/3/735
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https://www.mdpi.com/1420-3049/30/3/735

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